By Richard T. Walker (auth.), Erik De Clercq, Richard T. Walker (eds.)
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Extra resources for Antiviral Drug Development: A Multidisciplinary Approach
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23, 289 (1986). S. K. Robins in "Ribavirin-A--Broad Spectrum Antiviral Agent" p. 1, Ed. A. A. Kirkpatrick, Academic Press, 1980. L. G. Zavgorodny, U. V. L. Florentiev, Bioorg. , 12, 819 (1986). T. Ito, K. Ohba, M. Koyama,~. Sezaki, H. Tohyama, T. Shomura, H. Fukuyasu, Y. Kazuno, T. Niwa, M. Kojima, T. Niida, ~. , 37, 931 (1984). ~J. C. C. F. F. E. R. H. Verheyden, ~. Med. , 29, 671 (1986). ~E. F. Smee, M. Chernow, R. R. , 6, 299 (1986). C. L. M. B. Halstead, Antimicrob. , 24, 134 (1983). C. A.
R =H R = PO(OH)2 Most probably they act by attaching to part of the virus particle required to initiate penetration into a susceptible cell thus blocking the process. Rhinovirus 9 is particularly sensitive to the f1avan ~) but volunteers infected with this virus were not protected by oral administration of the compound. Similarly, the 45 chalcone (34) and the pro-drug (35) had no effect when given orally to volunteers carrying rhinovirus infections. It is quite possible that the concentrations of flavan and chalcone obtained in the nasal mucosal cells were not sufficiently high to afford protection.