Paul C. Guest's Biomarkers and Mental Illness: It’s Not All in the Mind PDF

By Paul C. Guest

Employing obtainable language all through, this publication covers the background of psychiatric examine, the present state-of-the artwork in psychiatric perform, the physiological structures suffering from psychiatric health problems, the whole-body nature of those illnesses and the impression that this element has on rising biomarker discoveries.

Further, it offers descriptions of the most important particular psychiatric issues and the distinct demanding situations concerning the analysis and remedy of every. The e-book concludes with insights into the most recent advancements in handheld biomarker attempt units, which may offer diagnostic info in under quarter-hour in point-of-care settings.

This publication investigates the rising use of biomarkers within the examine of psychiatric illnesses, an issue of substantial significance for a vast diversity of individuals together with researchers, clinicians, psychiatrists, college scholars or even these whose lives are affected not directly by way of a psychiatric ailment. The final class is not often trivial, in view that a marvelous one in 3 humans around the world express the factors for no less than one psychiatric affliction sooner or later of their lifetime.

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When tested 6 months later, the patient showed no hypoglycaemia and improved psychiatric symptom scores, associated with improved personal and social functioning. Since the patient stilled showed some mild depressive symptoms, the antidepressant was prescribed for 1 more year. This is another illustration of a case of a suspected psychiatric condition which was actually caused by a somatic condition—in this case the culprit was a tumour called an insulinoma. These tumours produce high levels of insulin, the main hormone responsible for reducing blood sugar levels.

24 2 Treatment of Psychiatric Disorders: Time for a Paradigm Change? Severity Treatment Normal diagnosis Treatment Early diagnosis Time Insult/trigger Inflammation Tissue effects Symptomatic disease Fig. 2 Time-based diagram showing that early diagnosis combined with effective treatment can lead to better outcome for the patients Most researchers and clinicians are now aware of the fact that the DSM system does not take into account the underlying biological causes of the disorders described in the various diagnostic categories.

Another aspect which could be tested is whether or not the patients of a particular biomarker group have any common clinical characteristics, such as similar prognoses or responses to treatment. An initial form of this approach has been advocated by Van Praag, who defined some basic symptom groups. Obviously, there are a number of assumptions associated with this approach. The most important of these is that circulating biomarker differences occur and that these differences reflect underlying changes that are common in a particular subgroup of patients.

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