By Mathurin-Jacques Brisson
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Extra resources for Dictionnaire raisonne de physique, par M. Brisson
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In this respect, it has been shown that 5-HT is less potent in stimulating phosphatidylinositol hydrolysis at edited versions of the 5-HT2C receptor than at the nonedited 5-HT2C receptor isoform INI. All these considerations should be kept in mind when considering the literature data on 5-HT2C receptor agonists. 4) were among the first nontryptamine 5-HT2C receptor agonists to be identified and still are commonly used as tools to probe 5-HT2C receptor function (Porter et al. 1999). 4 Arylpiperazine-based 5-HT2C receptor agonists many arylpiperazine based 5-HT2C receptor agonists have been reported (Fig.
Dremencov E, Weizmann Y, Kinor N, Gispan-Herman I, Yadid G (2006) Modulation of dopamine transmission by 5HT2C 5HT3 receptors: a role in the antidepressant response. Curr Drug Targets 7:165–175. 26 G. Mengod Eberle-Wang K, Mikeladze Z, Uryu K, Chesselet MF (1997) Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats. J Comp Neurol 384:233–247. Fitzgerald LW, Iyer G, Conklin DS, et al (1999) Messenger RNA editing of the human serotonin 5-HT2C receptor.
1984a, b; Hoyer et al. 1985). The 5-HT1C receptor was cloned soon thereafter (Julius et al. 1988). The knowledge of the messenger ribonucleic acid (mRNA) sequence and the derived protein sequence of these receptors allowed the development of new important tools for the study of their chemical neuroanatomy. The autoradiographic localization of 5-HT2C receptors had suffered from the lack of selective ligands. While mesulergine remains the ligand of choice, 5HT2C sites can also be labeled by other ligands such as 5-HT self, LSD (lysergic acid diethylamide), and DOI (1-(2,5-dimethoxy-4-iodophenyl-2-aminopropane), but G.